The newest scientific research reports that the amino acid leucine is the anabolic powerhouse due to its major role in activating protein synthesis and simulating a higher rate of muscle growth and repair via the mTOR anabolic pathway. This makes leucine the most critical BCAA for promoting overall protein synthesis for peak muscle building. BCAA 3300 utilizes a highly anabolic 4:1:1 branched chain amino acids ratio that contains four times the amount of the leucine to isoleucine and valine. The unique timed release delivery system provides a steady supply of these key BCAAs. This allows for a continual supply and maximum absorption and utilization of these critical aminos for superior strength and muscle building, anti-catabolic muscle protection, energy production and recovery over conventional BCAA formulas.

MHP’s BCAA 3300 is the most sophisticated, advanced anabolic BCAA formula available and is a must for all serious weight lifters and bodybuilders looking to increase their strength and muscularity to new extreme levels! 

LEUCINE CRITICAL FOR mTOR SIGNAL FOR PROTEIN SYNTHESIS

After exercise, recovery of muscle protein synthesis requires dietary protein or BCAAs to increase tissue levels of leucine in order to release the inhibition of the initiation factor 4 complex through the activation of the protein kinase mammalian target of rapamycin (mTOR). Leucine’s effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake. (Layne Norton and Donald Layman, Journal of Nutrition, 2006.)

BCAAs AND LEUCINE IMPROVE RECOVERY AND REDUCE SORENESS

Exercise may increase BCAA requirement, and BCAA supplementation before exercise attenuates the breakdown of muscle proteins during exercise. Leucine strongly promotes protein synthesis in skeletal muscle, suggesting that a BCAA supplement may attenuate muscle damage induced by exercise and promote recovery from the damage. Findings also suggest that BCAAs may be useful for muscle recovery following intense exercise, as BCAA supplementation before training decreased delayed-onset muscle soreness after squatting exercise. (Yoshiharu Shimomura, et al., Journal of Nutrition, 2006.)

BCAAs INCREASE ENDURANCE EXERCISE CAPACITY

Supplementation with BCAAs was shown to increase the lactate threshold before exhaustion in high-intensity exercise on a cycle ergometer. Subjects using BCAAs had noticeably higher plasma BCAA concentrations than the non-supplemented group, in addition to higher respiratory exchange ratio and both VO2 max and VO2 workload levels. These results suggest that BCAA supplementation may be effective to increase endurance exercise capacity. (Keitaro Matsumoto, et al., Journal of Nutritional Science Vitaminol, 2009.)

BCAA SUPPLEMENTATION PREVENTS CATABOLISM

Exercise is known to deplete serum BCAA levels via oxidation. BCAA supplementation before and after intense exercise has beneficial effects for decreasing exercise-induced muscle damage and promoting muscle protein synthesis. This suggests that BCAAs are a useful supplement in relation to exercise and sports. (Yoshiharu Shimomura, et al., Journal of Nutrition, 2004.)